Pitch 2-6 :BioPrint without BioPrinter-Artificial Organ and Disease Model

[Summary]

With revelation of fundamental components and composition of the cells, there was an advent of bioprinting that created an architectural design of the interior of the cell. Bioprinting is the three-dimensional printing of biological tissue and organs through the layering of living cells. This sort of printing is done through bioprinters. However, they lack precision.

TissueByNet is a start-up that came up with a unique bioprinting machine called Net Mold. It consists of two main parts, a Fine Net and a Space Net. They remain stuck to each other forming a Net Cavity in which cell aggregation takes place. The cells that are larger than 100 microns remains trapped in the net that is put in a media and cultured. The culture media gets access to the cells from all dimensions.

Likewise, cardiac patch or making a part of the heart, cartilage patch or hepatocytes or liver patch have also been developed based on the above concept. The collaborative research is in progress with Tokyo Women's Medical University and John Hopkins's University, which aims at working on various disease models. Currently, the work on Patient Derived Cancer Invasion Model, in collaboration with the University of Tokyo, is under progress.

They now have a goal of meeting companies from around the globe for the joint development and investment in the advanced research idea.

[Mentors' comments]

　"Very interesting the other thing of course you could think about is putting in growth factors or factors to encourage vascular genesis like STF1 or something like that, that mobilize blood supply."Dr. Kevin Grimes, Stanford University

[Profile]

Mr. Ono has experience in international business development field, which includes 3D-Bioprinter and blue laser diode for life science applications. He invented a simple device to fabricate 3D tissue and started business in 2017.