Vladimir Krechikov, Expert in Clinical trials, PatientFacient

Innovative approach for patient enrollment in clinical trials (PatientFacient/Wirano platform)

Vladimir Krechikov, Expert in Clinical trials, PatientFacient / Wirano

[Summary]
- Who is your client? What do you provide to them? What kind of social impact do you want to provide to them?

Our clients are pharma companies, CRO, study sites and patients. The goal of the project is to launch an intelligent cloud collaboration platform that has key capabilities:
• gives patients instant access to all ongoing clinical trials in every region/country/city;
• engages doctors who are passionate about advancing medical science;
• helps sites to find patients and act as referral sites with tracking of referred patients;
• allows pharma to popularize its research and speed up enrollment.

For patients:
• Intuitive online tool to locate appropriate clinical trials with dedicated patient-to-clinical site messenger and easy connectivity features
• Automatic translation service from English to local participant language
• Dedicated news channel with filters for areas of interest

For Doctors (Investigators):
• Dedicated investigator-to-patient peer-to-peer messenger
• Embedded sponsor-to-patient and sponsor-to-investigator financial transactions system
• Dashboards and business analytics on enrollment process with participants

For Pharma (Sponsors):
• Comprehensive online tool for feasibility analysis
• An AI-powered search engine that finds investigators with forecast and scoring features
• Built-in business processes allowing for rapid deployment of clinical trials via engagement of a preselected pool of investigators
• Dashboards with business analytics on enrollment in past and ongoing trials

The social impact is simplification of patient enrollment process. Nowadays patient recruitment is one of the biggest bottlenecks in clinical research: 50% of clinical trials fail to meet planned enrollment targets(1) ; 11% of clinical trial sites do not recruit a single patient(2) ; half of sites under - enroll (3).

- What is your technology? What is your superiority among competitors and how far is it in development?

The web-based software application has cloud data storage and centralized logic of information processing for events and facts with multi-criteria decision-making technology.
A built-in financial system tracks fact of events and links to the elements of the business process, which writes off from the sponsor's deposit account the cost of services that a sponsor uses. The transfers are process from sponsors to researchers and, in some cases, to referring sites and patients. Services are automatically writing off money from accounts only after a confirmation of dedicated system events.

The PatientFacient/Wirano platform distinguishes between four types of role-based interfaces: a sponsor, a researcher, a referral site (a doctor who does not conduct clinical trials himself but can refer his patients) and the participant - patient. Each role has its own interface in a dedicated cabinet.

Our superiority is very ergonomic and user-friendly cloud-based software powered by intelligent features to fast communicate and enroll patients with clinical trials. Now we have an interactive user-friendly tool with patient's cabinet and dedicated messenger to enroll patients to clinical trials. Our tool obtains data from open-source local clinical trial registries, analyzes it and provides in user friendly format.

- Where is your market, and how large is it? Who is your forerunner in the market?

According to Grand View Research, CRO market size will reach $54.7 Billion by 2025 with increasing costs of drug development driving the growth. Our B2B business model targets Pharma, Biotech and CRO companies.

Ecosoft health, Clinical trial connect, Patient Wing, Subject well, Find me cure, Ripple science, Deep6 are all English-only patient and trial databases. They are mostly located in the United States.

There is currently no comprehensive global multilingual platform that is capable of servicing international clinical trials.

- Who is in your team? What are their background and what strengths do they have in bringing your idea/technology to life?

The key team members are: Andrey Tarakanov, MD, MBA, Vladimir Krechikov, MD, PhD, MSc and Sergey Kotov, PM GAPPS.

Dr. Andrey Tarakanov graduated from Moscow Medical Academy and completed residency in Oral and Maxillofacial Surgery followed by more than 10 years of intensive surgery practice. Since 2004, Andrey has continued his career in the field of clinical research and in 2007, Dr. Tarakanov and his partner launched several successful projects in clinical trials, which are actively developing on the international market. Andrey's extraordinary organization and interpersonal skills make him one of the most sought-after top managers in the clinical research industry.

Vladimir Krechikov graduated from Smolensk Medical Academy, then received his postgraduate training at Queen Mary University of London and received PhD in clinical pharmacology. Vladimir participated in clinical trials as investigator, then worked in clinical operations in a global contract organization (CRO) and as a head of business development in a local CRO and as a head of business development, and currently holds executive position at one of the leading European CRO. With more than 15 years of expertise and intricate knowledge of every aspect of clinical research, Dr. Krechikov adds significant value to the project.

Sergey Kotov graduated from St. Petersburg State Marine Technical University, then conducted research in the field of artificial intelligence, automatic control systems and decision making systems. As a project manager Sergey has passed professional certification in PMA, IPMA and GAPPS and implemented many projects on large enterprise automation systems and business analytics. Sergey continues his research on the theory of thinking and adaptive systems for intelligence improvement. He is the creator of one of the best Russian language informational websites on the theory of management "Phenomenon of enterprise".
As the Project Director and Project Manager Sergey completed many complex and innovative IT-projects, including a warehouse logistics, a retail management system, BSC (KPI) and business intelligence dashboards, a robotic contact center, enterprise resource planning applications, an operational system for Russian post offices, and a mobile application to improve brain activities.
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(1) KA Getz. Uncovering the drivers of R&D costs. Proprietary presentation 2015, citing data from the Tufts Center for the Study of Drug Development.
(2) Kaitlin, K.I., Editor. "89% of trials meet enrollment, but timelines slip, half of sites under-enroll." Tufts Center for the Study of Drug Development Impact Report. 2013 Jan/Feb; 15(1).
(3) "Unclogging the Patient Recruitment Bottleneck", Pharma Voice, Feb. 2011, https://xtalks.com/Site-Selection-For-Clinical-Trials/

[Profile]
Vladimir Krechikov graduated from Smolensk Medical Academy (Russia), then received his postgraduate training at Queen Mary University of London (UK) and received PhD in clinical pharmacology. Vladimir participated in clinical trials as investigator, then worked in clinical operations in a global contract organization (CRO) and as a head of business development in a local CRO and as a head of business development, and currently holds executive position at one of the leading European CRO. With about 20 years of expertise and intricate knowledge of every aspect of clinical research, Dr. Krechikov adds significant value to the project.